کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1257529 971567 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Energy barriers, pathways, and dynamics during folding of large, multidomain RNAs
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Energy barriers, pathways, and dynamics during folding of large, multidomain RNAs
چکیده انگلیسی

Large, multidomain RNA molecules are generally thought to fold following multiple pathways down rugged landscapes populated with intermediates and traps. A challenge to understanding RNA folding reactions is the complex relationships that exist between the structure of the RNA and its folding landscape. The identification of intermediate species that populate folding landscapes and characterization of elements of their structures are the key components to solving the RNA folding problem. This review explores recent studies that characterize the dominant pathways by which RNA folds, structural and dynamic features of intermediates that populate the folding landscape, and the energy barriers that separate the distinct steps of the folding process.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 12, Issue 6, December 2008, Pages 655–666
نویسندگان
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