کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1257541 971567 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expanding the functional diversity of proteins through cysteine oxidation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Expanding the functional diversity of proteins through cysteine oxidation
چکیده انگلیسی

The polarizable sulfur atom in cysteine is subject to numerous post-translational oxidative modifications in the cellular milieu, which regulates a wide variety of biological phenomena such as catalysis, metal binding, protein turnover, and signal transduction. The application of chemical rationale to describe the features of different cysteine oxoforms affords a unique perspective on this rapidly expanding field. Moreover, a chemical framework broadens our understanding of the functional roles that specific cysteine oxidation states can play and facilitates the development of mechanistic proposals, which can be tested in both biochemical and cellular studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 12, Issue 6, December 2008, Pages 746–754
نویسندگان
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