کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1257808 1496498 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spatial mutation of the T cell immunological synapse
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Spatial mutation of the T cell immunological synapse
چکیده انگلیسی

The hardware for intracellular signaling networks consists of cascades of chemical reactions. It is becoming increasingly apparent that the large-scale spatial organization of molecules in these networks can lead to differential outcomes from otherwise chemically equivalent systems. This has amplified interest in controlled spatial organization as a regulator of cellular signal transduction. In response, a new category of experimentation is developing, in which the spatial positions of signaling molecules in living cells are directly manipulated through mechanical means. These methodologies complement conventional genetic and pharmacological approaches, both of which are chemical in nature, by perturbing the system through exclusively physical mechanisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 10, Issue 6, December 2006, Pages 544–550
نویسندگان
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