کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1257906 971588 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microbial nickel metalloregulation: NikRs for nickel ions
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Microbial nickel metalloregulation: NikRs for nickel ions
چکیده انگلیسی

Nickel is a required co-factor for several microbial enzymes; however, because of its potential toxicity, nickel import and homeostasis must be tightly controlled. Recent biophysical and biochemical studies have revealed that NikR proteins are a new type of metalloregulatory protein that utilize allostery and coordination geometry to sense nickel ions and regulate transcription of genes involved in nickel import and processing. Nickel import into bacteria occurs through either ABC-type transporters (NikABCDE) or HoxN type permeases (NixA). Recent structural evidence suggests that nickel is transported through NikABCDE as a metallophore (akin to a siderophore). Nickel storage is accomplished via the HPN protein, a histidine-rich protein similar to metallothionein.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 10, Issue 2, April 2006, Pages 123–130
نویسندگان
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