کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1259001 1496481 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metabolic control of methylation and acetylation
ترجمه فارسی عنوان
کنترل متابولیک متیلاسیون و استیلیت
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی


• Epigenetic methylation and acetylation are sensitive to cellular metabolic status.
• Diet and environment conditions shape epigenetics through metabolism.
• Stem cells rewire metabolism to maintain open chromatin structure.
• Oncometabolites cause cancer by interfering with DNA and histone demethylation.

Methylation and acetylation of DNA and histone proteins are the chemical basis for epigenetics. From bacteria to humans, methylation and acetylation are sensitive to cellular metabolic status. Modification rates depend on the availability of one-carbon and two-carbon substrates (S-adenosylmethionine, acetyl-CoA, and in bacteria also acetyl-phosphate). In addition, they are sensitive to demodification enzyme cofactors (α-ketoglutarate, NAD+) and structural analog metabolites that function as epigenetic enzyme inhibitors (e.g., S-adenosylhomocysteine, 2-hydroxyglutarate). Methylation and acetylation likely initially evolved to tailor protein activities in microbes to their metabolic milieu. While the extracellular environment of mammals is more tightly controlled, the combined impact of nutrient abundance and metabolic enzyme expression impacts epigenetics in mammals sufficiently to drive important biological outcomes such as stem cell fate and cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 30, February 2016, Pages 52–60
نویسندگان
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