کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1259137 1496485 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selection of multiple agonist antibodies from intracellular combinatorial libraries reveals that cellular receptors are functionally pleiotropic
ترجمه فارسی عنوان
انتخاب آنتی بادی های آگونیست چندگانه از کتابخانه های ترکیبی داخل سلولی نشان می دهد که گیرنده های سلولی از لحاظ عملکردی پلئوتروپیک هستند
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی


• Orthogonal agonists such as antibodies for a given receptor can induce cell fates different than the natural ligand.
• As examples, an antibody agonist that activates DDR1 induces osteoclasts from bone marrow stem cells whereas those against UNC5C or the G-CSF receptor induce bone marrow stem cells to become neural cells.
• The phenomenon of functional receptor pleiotropism greatly expands signal transduction potential of cells.
• Increasing the signal transduction potential allows one greater control over cell fates.

The main purpose of this perspective is to build on the unexpected outcomes of previous laboratory experiments using antibody agonists to raise questions concerning how activation of a given receptor can be involved in inducing differentiation of cells along different pathways some of which may even derive from different lineages. While not yet answered, the question illustrates how the advent of agonists not present in nature may give a different dimension to the important problem of signal transduction. Thus, if one studies a natural agonist–receptor system one can learn details about its signal transduction pathway. However, if one has a set of orthogonal agonists, one may learn about the yet undiscovered potential of the system that, in the end, may necessitate refinements to the currently used models. Thus, we wonder why receptors conventionally linked to a given pathway induce a different pattern of differentiation when agonized in another way.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 26, June 2015, Pages 1–7
نویسندگان
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