Combining biocatalysis and chemoselective chemistries for glycopeptide antibiotics modification

► Glycopeptide antibiotics are classified into five subtypes. ► Sulfation modification of glycopeptide has been achieved using sulfotransferases. ► Naturally occurring glycopeptide was modified via aglycone and sugar exchanges. ► Glycopeptide analogs were amidated and aminated on a given sugar moiety.