کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1272473 | 1496932 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Antiproliferative effect of millimeter radiation on human erythromyeloid leukemia cell line K562 in culture: Ultrastructural- and metabolic-induced changes Antiproliferative effect of millimeter radiation on human erythromyeloid leukemia cell line K562 in culture: Ultrastructural- and metabolic-induced changes](/preview/png/1272473.png)
In the present study we compared the proliferation behavior, the ultrastructural morphology and the glycolitic metabolism of K562 cells irradiated by low-power wide-band millimeter waves, with those of sham-exposed K562 cells (control), maintained in the same culture conditions. The gigaHertz radiation treatments, performed between 53–78 109 Hz, induced a noticeable inhibition of the cell proliferation that could be related to relevant ultrastructural changes. Such effects brought the irradiated cell system to lose the homeostasis and to trigger defense/reparatory mechanisms in order to reestablish a new steady state. 13C-Nuclear magnetic resonance data on the kinetic of glucose metabolism demonstrated that the irradiated cells enhanced the glycolitic aerobic pathway, indicating that such system need to produce an extra-bioenergy. Most of the ATP synthesized served probably to perform the above processes resulting in a significant decrease of the proliferation rate without significant cell death increment.
Journal: Bioelectrochemistry - Volume 70, Issue 2, May 2007, Pages 214–220