Hyperbranched polyester poly(3-diethylaminepropionate)s and their copper(II) complexes: Synthesis, characterization and biological investigation

• New hyperbranched poly(esteramine)s of the 2nd and 3rd generation were synthesized.
• Block mechanism of hyperbranched poly(esteramine)s ionization was established.
• Polynuclear Cu(II) complexes with hyperbranched poly(esteramine)s were obtained.
• The poly(esteramine) and its Cu(II) complex exhibit antifungal activity.
• Nanoparticles (D = 106 nm) in the poly(esteramine) Cu(II) complex film were indicated.

New polydentate ligands based on hyperbranched second and third generation polyesters containing terminal (3-diethylamino)propionate fragments and their polynuclear copper(II) complexes were synthesized and characterized by spectroscopic methods. The acid-base properties spectroscopy determined that the functionalization degree of the diethylamine-modified hyperbranched polyesters (LI, LII) increases from the second (56%) to third (81%) generation. The polynuclear complexes Cu(II)–LI and Cu(II)–LII were observed. A coordination site of the complexes contains paramagnetic fragment CuN2O2Solv2 where Solv is H2O or DMSO. The hyperbranched poly(ester amine) of the third generation have strong antifungal activity against Aspergillus fumigatus culture, and its metal complex is active against Candida albicans culture.

New polydentate ligands based on hyperbranched second and third generation polyesters containing terminal (3-diethylamino)propionate fragments and their polynuclear copper(II) complexes were synthesized. The hyperbranched poly(ester amine) of the third generation exhibits strong antifungal activity against Aspergillus fumigatus culture, and its metal complex is active against Candida albicans culture.Figure optionsDownload as PowerPoint slide