Preparation and catalytically study of metal–organic frameworks of amine/MIL-53 (Al) as a powerful option in the rapid N-formylation condensation in neat conditions

• An efficient and waste-free approach for organic synthesis.
• Amine/MIL-53 (Al) MOF that provide a synergistic means of a suitable mesochannels to drive out the products and water for next recycles.
• Represents advantages, operational simplicity, higher yield and easy filterable workup.

This paper reports on the preparation and application of amine/MIL-53 (Al) as highly active catalysts for the N-formylation reaction. These Al-MOFs were found to be an efficient, selective and waste-free green solid catalyst for the net condensation of amines and formic acid. The catalyst can be isolated from the reaction mixture and reused at least 6 times.

The metal–organic frameworks of amine/MIL-53 (Al) was found to be an efficient, selective and waste-free green solid catalyst for the net condensation of amines and formic acid.Figure optionsDownload as PowerPoint slide