کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1306678 | 975099 | 2010 | 7 صفحه PDF | دانلود رایگان |
A series of new, water soluble titanocene dichloride derivatives containing chiral alkylammonium groups have been synthesized and characterized and their cytotoxicities against the human lung cancer cell lines A549, H209 and H209/CP have been assessed. The potencies of the compounds vary greatly, with primary ammonium salts being particularly ineffective. However, mono- and dicationic derivatives containing chiral ephedrine-type functional groups are very effective, in particular the dicationic species.
A series of new titanocene dichloride derivatives containing chiral alkylammonium groups have been synthesized and characterized and their cytotoxicities against the human lung cancer cell lines A549, H209 and H209/CP have been assessed. Mono- and dicationic derivatives containing chiral ephedrine-type functional groups are very effective, in particular the dicationic species.Figure optionsDownload as PowerPoint slide
Journal: Inorganica Chimica Acta - Volume 364, Issue 1, 15 December 2010, Pages 16–22