کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1306678 975099 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A new series of titanocene dichloride derivatives bearing chiral alkylammonium groups; assessment of their cytotoxic properties
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
A new series of titanocene dichloride derivatives bearing chiral alkylammonium groups; assessment of their cytotoxic properties
چکیده انگلیسی

A series of new, water soluble titanocene dichloride derivatives containing chiral alkylammonium groups have been synthesized and characterized and their cytotoxicities against the human lung cancer cell lines A549, H209 and H209/CP have been assessed. The potencies of the compounds vary greatly, with primary ammonium salts being particularly ineffective. However, mono- and dicationic derivatives containing chiral ephedrine-type functional groups are very effective, in particular the dicationic species.

A series of new titanocene dichloride derivatives containing chiral alkylammonium groups have been synthesized and characterized and their cytotoxicities against the human lung cancer cell lines A549, H209 and H209/CP have been assessed. Mono- and dicationic derivatives containing chiral ephedrine-type functional groups are very effective, in particular the dicationic species.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Inorganica Chimica Acta - Volume 364, Issue 1, 15 December 2010, Pages 16–22
نویسندگان
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