کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1307096 | 1499187 | 2013 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Properties and biological activity of [Rh(COD)(N–N)]BF4 and [IrCl2(COD)(N–N)]BF4 polypyridyl complexes Properties and biological activity of [Rh(COD)(N–N)]BF4 and [IrCl2(COD)(N–N)]BF4 polypyridyl complexes](/preview/png/1307096.png)
Square planar rhodium(I) complexes [Rh(COD)(N–N)]BF4 (COD = 1,5-cyclooctadiene, N–N = 1,10-phenanthroline (phen) (1), 2,2′-bipyridine (bpy) (2), 4,7-diphenyl-1,10-phenanthroline (dpphen) (3), 4,4′-dimethyl-2,2′-bipyridine (dmbpy) (4), dipyrido[3,2-a:2′,3′-c]-phenazine (dppz) (5), 2,9-dimethyl-1,10-phenanthroline (dmphen) (6)) and octahedral iridium(III) complexes [IrCl2(COD)(N–N)]BF4 (COD = 1,5-cyclooctadiene, N–N = 1,10-phenanthroline (phen) (7), 2,2′-bipyridine (bpy) (8), 4,4′-dimethyl-2,2′-bipyridine (dmbpy) (9)) have been obtained and characterized using spectroscopic methods. They are active agents towards Caco-2, Sk-mel, SNB-19 and C-32 tumor cells. Complexes 3, 5 and 6 are also efficient antibacterial agents against Gram-positive bacteria and compound 3 shows antifungal activity against AD1–9 and FY yeast strains.
Cyclooctadiene complexes [Rh(COD)(N–N)]BF4 and [IrCl2(COD)(N–N)]BF4 with 1,10-phenanthroline, 2,2′-bipyridine and their derivatives are active agents against Caco-2, Sk-mel, SNB-19 and C-32 tumor cells. The most effective cytostatic agents are compounds with 4,7-diphenyl-1,10-phenanthroline and dipyrido[3,2-a:2′,3′-c]-phenazine (dppz). They are also efficient antibacterial agents against Gram-positive bacteria.Figure optionsDownload as PowerPoint slideHighlights
► Rhodium(I) and iridium(III) complexes with polypyridyl ligands have been prepared.
► All complexes show high antitumor activity.
► The iridium complexes are considerably more active than cisplatin.
► Rhodium compounds are active agents against Gram-positive bacteria.
Journal: Inorganica Chimica Acta - Volume 400, 1 May 2013, Pages 26–31