Synthesis, structural characterization and biological screening of heteroleptic palladium(II) complexes

• Ten heteroleptic palladium(II) complexes have been synthesized in good yields.
• The XRD analyses have exhibited pseudo square-planar geometry.
• The absorption peak is observed in the range of 1510–1526 cm−1, which is intermediate between a single bond CN (1250–1350 cm−1) and a double bond CN (1640–1690 cm−1).
• The synthesized have shown moderate anticancer and antibacterial activity.

Heteroleptic palladium(II) complexes of the type formula [(DTC)(Pd)(PR3)Cl], where DTC = bis(2-ethylhexyl)dithiocarbamate (1, 8, 9, 10), bis(2-methoxyethyl)dithiocarbamate (2), di-n-decyldithiocarbamate (3, 6), di-n-hexyldithiocarbamate (4, 7), bis(2-methylbutyl)dithiocarbamte (5); PR3 = diphenyl-t-butylphosphine (1), diphenyl-n-propylphosphine (2), triphenylphosphine (3, 4, 5, 10), diphenyl-p-tolylphosphine (6, 7, 8), diphenylbenzylphosphine (9); have been synthesized and characterized by FTIR, Raman, multinuclear and multinuclear NMR (1H, 13C, 31P) spectroscopy and elemental analyses. The structures of complexes (1 and 2) were determined by single-crystal X-ray diffraction. The geometries around the metal centers are pseudo square-planar. The new complexes exhibit moderate anticancer and antibacterial activity.

Mixed ligand Pd(II) complexes have been synthesized in good yields. All the complexes were characterized by analytical and spectroscopic techniques. The prepared compounds have shown moderate antitumor and antibacterial activity.Figure optionsDownload as PowerPoint slide