Rhodium-catalyzed arylation of α-amido sulfones with arylboronic acids in a water–toluene biphasic system

An efficient method for the synthesis of N-protected diaryl-methyl-amines was developed through a rhodium-catalyzed arylation of α-amido sulfones with arylboronic acids in a water–toluene biphasic system. The use of a base combined with a surfactant played a key role in this biphasic reaction. A diverse range of α-branched amine derivatives bearing different functional groups were obtained within 10 min under the present conditions.

A rhodium-catalyzed efficient synthesis of N-carbamate protected diarylmethyl-amines was developed through the arylation of α-amido sulfones with arylboronic acids in a water–toluene biphasic system. A diverse range of N-carbamate protected α-branched-amines bearing several functional groups were obtained within 10 min. The uses of K2CO3 as a base and sodium dodecyl sulfate as a surfactant combined with a water–toluene biphasic system play a key role in the reaction.Figure optionsDownload as PowerPoint slide