Synthesis, crystal structures and in vitro anti-fungal activities of two silver(I) coordination polymers with fluconazole

Two new polymeric silver(I)-fluconazole complexes: [Ag(HFlu)(NO3)]n (1) and {[Ag(HFlu)2](ClO4)}n (2), have been synthesized and structurally characterized. The crystal structure of 1 consists of infinite 1D single strand helical coordination arrays with alternative …PMPM… arrangements, which are interlinked through hydrogen bonding interactions to generate a 3D network. The shortest intrachain Ag⋯Ag distance bridged by HFlu ligand is 8.287(1) Å. In 2, each Ag(I) ion is coordinated by four triazole N atoms from four HFlu ligands to form a 2D coordination layer, which has a helical arrangement along the [1 0 0] direction. The results of anti-fungal studies demonstrate that both silver(I) complexes are more active in comparison to the fluconazole drug.

Two silver(I)-fluconazole complexes [Ag(HFlu)(NO3)]n (1) and {[Ag(HFlu)2](ClO4)}n (2) have been synthesized, which display novel 1D and 2D helical coordination arrays. Both silver(I) complexes show higher anti-fungal activities compared to the fluconazole drug.Figure optionsDownload as PowerPoint slide