کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1308363 1499147 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Part XXIII. Synthesis and characterization of platinum(IV) complexes with O,O′-dialkyl esters of (S,S)-ethylenediamine-N,N′-di-2-(3-methyl)butanoic acid and bromido ligands. Antimicrobial, antibiofilm and antioxidant screening
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Part XXIII. Synthesis and characterization of platinum(IV) complexes with O,O′-dialkyl esters of (S,S)-ethylenediamine-N,N′-di-2-(3-methyl)butanoic acid and bromido ligands. Antimicrobial, antibiofilm and antioxidant screening
چکیده انگلیسی


• Four new platinum(IV) complexes with edda-type of ligand were synthesized.
• Characterized by microanalysis, infrared, 1H and 13C NMR spectroscopy.
• Antimicrobial, antibiofilm and antioxidant screening.

Four new platinum(IV) complexes C1–C4 of general formula [PtBr4(R2-S,S-eddv)], (R = ethyl, propyl, butyl and pentyl; S,S-eddv = (S,S)--ethylenediamine-N,N′-di-2-(3-methyl)butanoate) have been synthesized and characterized by microanalysis, infrared, 1H and 13C NMR spectroscopy. In vitro antimicrobial activity for these and [PtBr4(R2-S,S-eddp)] complexes (S,S-eddp = (S,S)-ethylenediamine-N,N′-di-2-propanoate) has been investigated. The antibacterial activity was tested against 16 strains of bacteria determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) using microdilution method. In general, platinum(IV) complexes manifested moderate activity against the Gram positive bacteria and low activity against the Gram negative bacteria. The complexes showed weak antioxidative properties tested by two methods (DPPH and reducing power assay).

Four new platinum(IV) complexes have been obtained by reaction of potassium-hexabromidoplatinate(IV) with corresponding esters of (S,S)-ethylenediamine-N,N′-di-2-(3-methyl)butanoate. We investigated antimicrobial, antibiofilm and antioxidant activity of these and [PtBr4(R2-S,S-eddp)] complexes (S,S-eddp = (S,S)-ethylenediamine-N,N′-di-2-propanoate).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Inorganica Chimica Acta - Volume 442, 1 March 2016, Pages 105–110
نویسندگان
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