Immobilised zinc (II) cyclen complexes as catalytic reagents for phosphodiester hydrolysis

Many hydrolases found in nature have Zn(II) ions at their active site. Artificial hydrolases as alternatives for non-enzymatic hydrolysis were prepared by attaching Zn(II) cyclen complexes with an alcohol pendant to a polymeric support. These modified polymers showed a 104-fold enhanced intrinsic reactivity for the hydrolysis of activated phosphodiesters over the non-catalysed reaction in solution.

Zn(II) cyclen complexes with hydroxyl group were immobilised on a polymer and showed 104-fold rate enhancements for the hydrolysis of an activated phosphodiester compared to the non-catalysed reaction.Figure optionsDownload as PowerPoint slide