کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1308817 | 975186 | 2009 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Molecular structure and antitumor activity of platinum(II) complexes containing purine analogs Molecular structure and antitumor activity of platinum(II) complexes containing purine analogs](/preview/png/1308817.png)
Platinum(II) compounds containing purine analogs as ligands have gained increasing attention in pharmaceutical applications as, for example, antitumor drugs. This article reviews the molecular and antitumor properties of this class of compounds. The large amount of available spectroscopic and crystollographic data allows possible elucidation of geometrical parameters, such as bond lengths and angles, which may have an impact on the behavior of platinum(II) complexes against tumor cells.
Here, the molecular structure and antiproliferative activity in vitro of platinum(II) complexes containing purine analogs have been presented. The cytotoxicity of platinum(II) complexes is compared and possible structure–activity relationships are discussed.Figure optionsDownload as PowerPoint slide
Journal: Inorganica Chimica Acta - Volume 362, Issue 3, 20 February 2009, Pages 669–681