Synthesis, spectral characterization, antibacterial and antitumor studies of some diorganotin(IV) complexes derived from 2-phenylmonomethylglutarate

• In vitro antibacterial activity of organotin(IV) compounds is reported.
• Antitumor activity of tin(IV) complexes against human cell line KB was also recorded.
• For structural analysis spectral tool are used.
• All the compounds found to be potent.

A novel series of diorganotin(IV) complexes of the type R2SnL2 (R = Me, Et, Bu, Ph Bz and L = 2-phenylmonomethylglutarate) has been reported herein. The synthesized compounds has been characterized by elemental analysis and their solid state configuration has been determined by various spectroscopic (IR, 1H, 13C, 119Sn NMR, 119mSn Mössbauer) techniques. The results obtained are in full agreement with the proposed 2:1 stoichiometry. The title complexes have been screened against various Gram positive and Gram negative bacteria and human cell line KB, the results obtained showed that the diphenyltin(IV) complex exhibited excellent activity against all types of bacteria, while diethyltin(IV) complex was found to have promising antitumor activity.

Five novel organotin(IV) complexes have been synthesized by the reaction of 2-phenylmonomethylglutarate with diorganotin(IV) halides.Figure optionsDownload as PowerPoint slide