Synthesis, crystal structure and characterization of three novel copper complexes of Levofloxacin. Study of their DNA binding properties and biological activities

• Synthesis of copper complexes of Levofloxacin with hetero-ligands.
• Characterization of the fabricated complexes.
• X-ray structures.
• EPR study.
• MTT assay and IC50 determination.

Three novel copper(II) complexes of the antibacterial drug Levofloxacin (LVX), in the presence or absence of heterocyclic ligands such as 1,10-phenanthroline and 2,2-bipyridine, have been synthesized and fully characterized. The interaction of copper(II) with the deprotonated ligand LVX reveals that LVX coordinated to copper atom through the pyridone and one carboxylato oxygen. In case of the mixed ligand complexes the Cu atom is coordinated with two O atoms from LVX ligand and with two N atoms from the hetero-ligands. According to our results the formation of dimers is a typical characteristic for almost all of them. The presence of dimers in the crystal structure is also evident in the EPR spectra and this method can be used as a probe for the existence of such species. A significant characteristic of the structure is the intra- and inter-dimer π–π stacking interaction which governs the packing of complexes in the structure. The synthesized compounds were biologically evaluated. All the complexes show an increased biological activity in comparison with the free ligand.

Three novel copper(II) complexes of the antibacterial drug Levofloxacin (LVX), in the presence or absence of heterocyclic ligands such as 1,10-phenanthroline and 2,2-bipyridine, have been synthesized and fully characterized. In continuation the complexes were evaluated biological.Figure optionsDownload as PowerPoint slide