کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1309774 975220 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
1-Methylisocytosine as a ligand for (dien)MII (M = Pt, Pd) and Pt-promoted deamination to 1-methyluracil
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
1-Methylisocytosine as a ligand for (dien)MII (M = Pt, Pd) and Pt-promoted deamination to 1-methyluracil
چکیده انگلیسی

1-Methylisocytosine (1-MeIC) can be protonated at the endocyclic N(3) position (pKa of 1-MeICH+, 4.02 ± 0.04) or complexed at this position with (dien)MII (M = Pt, Pd). X-ray crystal structures of the protonated species 1 as well as the Pd (2) and Pt (3) complexes are reported, and gas phase structures of the cation 2 and 3 have been calculated by ab initio methods. These results are compared with results from X-ray crystallography. At high pH, the Pt complex 3 undergoes deamination of the exocyclic N(2)H2 group to the 1-methyluracilate complex. As compared to the situation with 1-methylcytosine (1-MeC), the accelerating effect of (dien)PtII is much less pronounced, however.

1-Methylisocytosine binds (dien)PtII via its N(3) position, thereby facilitating hydrolytic deamination of the exocyclic amino group in 2-position to give 1-methyluracilate.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Inorganica Chimica Acta - Volume 360, Issue 7, 2 May 2007, Pages 2379–2386
نویسندگان
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