کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1309801 1499170 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, characterization of ruthenium(II) complex of 1,3,8-trihydroxy-6-methyl-anthraquinone (emodin) and its binding behavior with c-myc G-quadruplex
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Synthesis, characterization of ruthenium(II) complex of 1,3,8-trihydroxy-6-methyl-anthraquinone (emodin) and its binding behavior with c-myc G-quadruplex
چکیده انگلیسی


• A novel ruthenium(II) complex of emodin has been synthesized.
• The binding behavior with c-myc G4 DNA has been further investigated.
• This complex could bind and stabilize the conformation of c-myc G-quadruplex.

In this paper, a novel ruthenium(II) complex of emodin, Ru(bpy)2Emodin(RBL17, bpy = 2,2'-bipyridine; Eomdin = 1,3,8-trihydroxy-6-methyl-anthraquinone), has been synthesized and characterized by ESI-MS, 1H NMR, 1H–1H COSY and electronic spectra. The binding behavior of RBL17 with c-myc G4 DNA has been further investigated by ITC (isothermal titration calorimetry), FRET (fluorescence resonance energy transfer) and 1H NMR spectra, as well as spectroscopic methods. Those results showed that this complex has the ability to bind and stabilize the conformation of c-myc G-quadruplex via groove binding mode. Taken together, ruthenium(II) complex of emodin can act as a potential inhibitor in chemotherapy by targeting to c-myc G4 DNA.

A novel ruthenium(II) complex of emodin has been synthesized and characterized, which has the ability to stabilize the conformation of c-myc G-quadruplex via groove binding mode.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Inorganica Chimica Acta - Volume 418, 1 July 2014, Pages 23–29
نویسندگان
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