کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1310558 1499193 2013 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A new series of Cs+, K+ and Na+ chelators: Synthesis, kinetics, thermodynamics and modeling
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
A new series of Cs+, K+ and Na+ chelators: Synthesis, kinetics, thermodynamics and modeling
چکیده انگلیسی

The synthesis of two molecules, B1 and B2, based on elements of norbadione A, the natural Cs+ chelator in mushrooms, associated, in the case of B2, with an 18-crown-6 ether is reported. Thermodynamic and kinetic analyses performed in water, ethanol and ethanol/water 9/1 v/v (M1) show in M1 and ethanol that B1 and B2 form stable complexes with Na+, K+ and Cs+. Affinity constants, measured spectrophotometrically in ethanol and M1, by the use of the Specfit program, are in the 105 and 106 range for B1 and B2, respectively. The second-order rate constants are in the 106–107 M−1 s−1 range and the first-order rate constants about unity. The ratios of the second-order/first-order rate constants confirm the thermodynamic results in EtOH. The kinetic processes become much too fast to allow runs in M1. Molecular simulations in EtOH imply the existence of two isomers for each of the Cs+/B1 and Cs+/B2 complexes. With B1, the more stable one is that in which the two enolates are parallel and mimic the alkali-metal inclusion cavity already envisaged for norbadione A. With B2, two similar structures are extracted, in both of which Cs+ is included in the crown ether and capped by the enolate. The affinity of B1 for Cs+ is comparable to that of norbadione A, whereas that of B2 is higher. These results are encouraging as they introduce a new series of alkali chelators which can lead to molecules capable of complexing 137Cs+ for radioactive decontamination.

Eventual structure of the cisoid B1–Cs+ complex.Figure optionsDownload as PowerPoint slideHighlights
► A new series of alkali metal sequestering agents which may be useful for decontamination after a nuclear accident.
► Chelator based on tetronic acids construction elements of norbadione A.
► Mimicking the inclusion cavity of crown ethers or calixarenes with high affinities for Na+, K+ and Cs+.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Inorganica Chimica Acta - Volume 394, 1 January 2013, Pages 45–57
نویسندگان
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