Novel hydrophilic cis-bis(cyclopentylamine)platinum(II) complexes: Synthesis, characterization, antitumor activity and interaction with DNA

► Three hydrophilic cisplatin-type complexes with two cyclopentylamine ligands. ► All complexes showed high in vitro cytotoxicity against HCT-116 and SGC7901. ► A different DNA unwinding pattern from cisplatin was observed.