کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1312619 | 975472 | 2010 | 8 صفحه PDF | دانلود رایگان |
A new synthetic route to the known tripodal tetradentate N3O ligand L1 (HL1 = [N-(3,5-di-tert-butyl-2-hydroxybenzyl)-N,N-di-(2-pyridylmethyl)]amine) is reported. The related compounds HLn (n = 2, 3) were prepared by a similar procedure. Treatment of HLn (n = 1–3) with FeCl3·6H2O in hot methanol led to the mononuclear iron(III) complexes [Fe(Ln)Cl2] (1: n = 1, 2: n = 2, 3: n = 3). The solid-state structures of complexes 1 and 2 were determined by X-ray crystallography. [Fe(L1)Cl2] (1) showed effective nuclease activity in the presence of hydrogen peroxide, converting supercoiled plasmid DNA to its linear form.
Mononuclear Fe(III) complexes of the general formula [Fe(Ln)Cl2] (1: n = 1, 2: n = 2, 3: n = 3), where Ln are N-capped tripodal tetradentate N3O ligands, were synthesised and structurally characterised. Complex 1 exhibited significant DNA cleavage activity in the presence of H2O2.Figure optionsDownload as PowerPoint slide
Journal: Inorganica Chimica Acta - Volume 363, Issue 6, 5 April 2010, Pages 1246–1253