کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1312631 | 975472 | 2010 | 4 صفحه PDF | دانلود رایگان |
To facilitate the development of PET radiopharmaceuticals labelled with the positron-emitting radioisotope copper-64 (t1/2 = 12.7 h) we have developed a fully automated method for its regular productions. Using the 64Ni(p,n)64Cu nuclear reaction applied on a 16.5 MeV PETtrace cyclotron the radioisotope is generated in good yields (up to 2 GBq at end-of-synthesis) within 4 h irradiations on nickel-64 (99.6% enrichment) plated onto a gold disk. Based on ion exchange chromatography an automated method has been devised for efficient extraction of the copper-64 in good radionuclide and chemical purity, with ICP-OES analysis determining the concentration of the copper to be 0.14–1.5 ppm. The specific radioactivities of the copper-64 at end-of-synthesis were calculated to be 9.62–77 GB/μmol. The copper-64 radioisotope obtained from this method was then applied to the radiosynthesis of the hypoxia markers, 64Cu-ATSM and 64Cu-ATSE, which were obtained in good radiochemical yields of >95%.
For the PET radioisotope copper-64, produced by the 64Ni(p,n)64Cu nuclear reaction, a fully automated method for its efficient extraction in high chemical purity has been devised. The radioisotope has then been applied to the radiosynthesis of the hypoxia markers, 64Cu-ATSM and 64Cu-ATSE in good radiochemical yield of >95%.Figure optionsDownload as PowerPoint slide
Journal: Inorganica Chimica Acta - Volume 363, Issue 6, 5 April 2010, Pages 1316–1319