کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1313108 975527 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural and antitumor activity study of γ-octamolybdates containing aminoacids and peptides
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Structural and antitumor activity study of γ-octamolybdates containing aminoacids and peptides
چکیده انگلیسی

γ-Type octamolybdates of the formulae, Na4[Mo8O26(alaO)2] · 18H2O (I), Na4[Mo8O26(glyglyO)2] · 15H2O (II) and Na4[Mo8O26(glyglyO)2] · 12H2O (III) have been prepared from sodium molybdate in aqueous solution by adding dl-alanine or glycylglycine. Their crystal structures have been determined by X-ray structure analysis. dl-alanine and glycylglycine coordinate molybdenum atom in γ-octamolybdate [Mo8O26]4− anions via monodentate carboxylate-oxygen atom. The prepared octamolybdates were screened for the possible antiproliferative activity on a panel of five tumor cell lines and on a normal cell line. All tested compounds showed a differential cell-growth inhibition in a dose-dependent manner selectively on hepatocellular carcinoma cell line (HepG2) and breast cancer cell line (MCF-7).

The crystal structures of γ-type octamolybdates Na4[Mo8O26(alaO)2] · 18H2O (I), Na4[Mo8O26(glyglyO)2] · 15H2O (II) and Na4[Mo8O26(glyglyO)2] · 12H2O (III) have been determined by X-ray structure analysis. These compounds are tested against different carcinoma cells in vitro. All tested compounds showed a differential cell-growth inhibition in a dose-dependent manner selectively on HepG2 and MCF-7 cell lines.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Inorganica Chimica Acta - Volume 359, Issue 5, 20 March 2006, Pages 1673–1680
نویسندگان
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