کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1313224 975542 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ruthenium(II) complexes containing asymmetric 2-(pyrazin-2-yl)naphthoimidazole: syntheses, characterization, DNA-binding and photocleavage studies
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Ruthenium(II) complexes containing asymmetric 2-(pyrazin-2-yl)naphthoimidazole: syntheses, characterization, DNA-binding and photocleavage studies
چکیده انگلیسی

A novel asymmetric bidentate ligand, 2-(pyrazin-2-yl)naphthoimidazole (PZNI), and its Ru(II) complexes [Ru(bpy)2(PZNI)]2+ (1) and [Ru(phen)2(PZNI)]2+ (2) have been synthesized and characterized by elemental analysis, mass spectra, 1H NMR, and electronic spectroscopy. The electrochemical behaviors of the novel complexes were studied by cyclic voltammetry. The DNA-binding properties of the complexes were investigated by spectroscopic methods and viscosity measurements. The experimental results indicate that the complexes 1 and 2 interact with calf thymus DNA by intercalative mode via the terminal naphthyl ring into the base pairs of DNA. The two Ru(II) complexes have also been found to promote the cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation.

Two novel ruthenium(II) complexes of [Ru(bpy)2(PZNI)]2+ (1) and [Ru(phen)2(PZNI)]2+ (2) have been synthesized and characterized. Their DNA-binding and photocleavage properties have also been investigated by spectroscopic methods, viscosity and electrophoresis measurements.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Inorganica Chimica Acta - Volume 358, Issue 6, 30 March 2005, Pages 1904–1910
نویسندگان
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