Protein-based ferrogels

• First synthesis of a protein-based ferrogel
• Size and magnetic properties of NPs dependent upon Fe to protein ratio
• These ferrogel particles can pass through pores with diameter smaller than the particles.
• The ferrogels can incorporate 24 mg of dye per gram of microparticle.

We present a novel synthesis in which hemoglobin and Fe2 + react, in the presence of KNO3 and KOH, to produce protein microgels that contain magnetic iron oxide nanoparticles. The synthesis results in microgels with polymer properties (denaturing and glass transition temperatures) that are consistent with the dried protein. The iron oxide nanoparticles that exhibit an average diameter of 22 nm, are ferrimagnetic, and display properties consistent with Fe3O4. The multiple functional capabilities displayed by these materials: biocompatibility, magnetism, dye uptake and controlled release, and other properties archetypal of hydrogels, will make the magnetic hydrogels attractive for a number of biomedical applications.

A protein templates and facilitates the synthesis of micrometer-sized hydrogels that contain iron oxide nanoparticles. This novel material, a protein-based ferrogel, is characterized and analyzed for its magnetic properties and its ability to uptake dye molecules.Figure optionsDownload as PowerPoint slide