From coordination chemistry to biological chemistry of aluminium

• The interactions of Al(III) with small biomolecules briefly summarised.
• The biospeciation of Al(III) in serum is discussed.
• The role of time in the distribution of Al(III) is considered in biological systems.
• The interactions of Al(III) with proteins/peptides and amino acids is reported.
• The application of l.m.m. chelators in the removal of the brain Al(III) is covered.

The paper gives a review on the importance of distribution of Al in biological fluids, primarily in the lights of the works of the author in Al chemistry. It starts with studies of interactions of Al(III) with small biomolecules, such as aliphatic and aromatic hydroxycarboxylic acids, and inorganic and organic phosphates. A significant part of this review deals with the problems of description of the biospeciation of Al(III) in serum, where besides the thermodynamic conditions the role of time is also considered in the case of this sluggish metal ion. The Al(III) complexes of the other large group of biomolecules, proteins and their building blocks (oligo)peptides and amino acids are also discussed, where the role of the type of the side chain donors and the extent of preorganisation are considered in the efficiency of metal ion binding. The application of low molecular mass chelator molecules in restoring the dysfunctioning metal ion (including Al(III)) homeostasis in the treatment of Alzheimer's disease is also discussed in the paper.

The paper discusses the interactions of Al(III) with small and large biomolecules including serum components and also the role of time in the distribution of this sluggish metal ion in a biological environment. The application of low molecular mass chelators in the removal of exogenous brain Al(III) is also considered.Figure optionsDownload as PowerPoint slide