کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1316034 976416 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hydroxyquinoline based binders: Promising ligands for chelatotherapy?
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Hydroxyquinoline based binders: Promising ligands for chelatotherapy?
چکیده انگلیسی

We report here a thorough physico-chemical study of the coordination properties of clioquinol, an oxine-type active neurological drug in Alzheimer's disease, toward biologically relevant divalent metal ions (Cu, Zn, Ni, Co and Mn). Using a fruitful combination of electrospray mass spectrometry, absorption spectrophotometry and potentiometry, we have characterized the mono- and bis-chelated metal ion species. The determination of the stability constants showed a classical thermodynamic behavior along the studied series with the cupric complexes being by far the most stable species. Our data are discussed within the scope of Alzheimer's disease.

The ionic recognition properties of Clioquinol have been re-investigated. Independently of the nature of the metal ion (Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)), mono- and bischelate species in solution were characterized.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 105, Issue 3, March 2011, Pages 490–496
نویسندگان
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