کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1316206 | 976436 | 2009 | 5 صفحه PDF | دانلود رایگان |
Due to the broad spectrum of biological activities of flavonoids, their target molecules in the cell are intensively studied. We examined the interactions of the flavonoid quercetin (Q) and its lanthanum complex (QLa3+) with very recently isolated plant viral satellite (sat) dsRNA. Comparison of the cumulative binding affinity and the estimated intercalative binding constant pointed towards an additional binding mode of quercetin to exclusively viral dsRNA, which is not recorded for synthetic dsRNAs. The QLa3+ showed significantly higher affinity toward viral dsRNA than Q and La3+ alone, most likely as the consequence of quercetin intercalation accompanied by additional electrostatic interaction of La3+ with the negatively charged viral RNA backbone.
Journal: Journal of Inorganic Biochemistry - Volume 103, Issue 12, December 2009, Pages 1597–1601