کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1316337 | 976451 | 2008 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs](/preview/png/1316337.png)
چکیده انگلیسی
A variety of substituted titanocene and ansa-titanocene complexes have been synthesized and characterized using traditional methods. The cytotoxic activity of the different titanocene complexes was tested against tumour cell lines human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, peripheral blood mononuclear cells PBMC. Alkenyl substitution, either on the cyclopentadienyl ring or on the silicon-atom ansa-bridge of the titanocene compounds [Ti{Me2Si(η5-C5Me4)(η5-C5H3{CMe2CH2CH2CHCH2})}Cl2] (8), [Ti{Me(CH2CH)Si(η5-C5Me4)(η5-C5H4)}Cl2] (9) and [Ti(η5-C5H4{CMe2CH2CH2CHCH2})2Cl2] (12) showed higher cytotoxic activities (IC50 values from 24 ± 3 to 151 ± 10 μM) relative to complexes bearing an additional alkenyl-substituted silyl substituent on the silicon bridge [Ti{Me{(CH2CH)Me2SiCH2CH2}Si(η5-C5Me4)(η5-C5H4)}Cl2] (10) and [Ti{Me{(CH2CH)3SiCH2CH2}Si(η5-C5Me4)(η5-C5H4)}Cl2] (11) which causes a dramatic decrease of the cytotoxicity (IC50 values from 155 ± 9 to >200 μM). In addition, the synthesis of the analogous niobocene complex [Nb(η5-C5H4{CMe2CH2CH2CH=CH2})2Cl2] (13), is described. Structural studies based on DFT calculations of the most active complexes 8, 9 and 12 and the X-ray crystal structure of 13 are reported.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 102, Issue 8, August 2008, Pages 1558-1570
Journal: Journal of Inorganic Biochemistry - Volume 102, Issue 8, August 2008, Pages 1558-1570
نویسندگان
Santiago Gómez-Ruiz, Goran N. KaluÄeroviÄ, Sanjiv Prashar, Dorian Polo-Cerón, Mariano Fajardo, Željko Žižak, Tibor J. Sabo, Zorica D. JuraniÄ,