کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1316445 | 976459 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interaction of the DNA bases and their mononucleotides with pyridine-2-carbaldehyde thiosemicarbazonecopper(II) complexes. Structure of the cytosine derivative
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Experimental studies of the binding interactions of [CuL(NO3)] and [{CuLâ²(NO3)}2] (HL = pyridine-2-carbaldehyde thiosemicarbazone, and HLâ²Â = pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) with adenine, guanine, cytosine, thymine and their mononucleotides (dNMP), 2-deoxyadenosine-5â²-monophosphate, (dAMP), 2â²-deoxyguanosine-5â²-monophosphate, (dGMP), 2â²-deoxycytidine-5â²-monophpsphate (dCMP), and thymidine-5â²-monophosphate (dTMP) have been carried out in aqueous solution at pH 6.0, I = 0.1 M (NaClO4) and T = 25 °C. The complexation constants of these compounds, calculated by Hildebrand-Benesi plots for the dye binding, D, ([CuL] or [CuLâ²]) to the nucleobases or nucleotides (P), have shown two linear stretches in adenine, guanine, dAMP and dGMP. The data were analyzed in terms of formation of 1:1 DP and 1:2 DP2 complexes with increasing purine base or nucleotide content. For cytosine and dCMP only 1:1 complexes have been observed, whereas for thymine and dTMP such complex structures were not observed. The [CuL(Hcyt)](ClO4) cytosine derivative has been isolated and characterized. The crystal structure consists of perchlorate ions and [CuL(Hcyt)]+ monomers attached by hydrogen bond, chelate Ïâring and anion-Ï interactions. The Cu2+ ions bind to the NNS chelating moiety of the thiosemicarbazone ligand and the cytosine N13 site (N3, most common notation) yielding a square-planar geometry. A pseudocoordination to the cytosine O12 site (=O2) can also be considered.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 102, Issue 10, October 2008, Pages 1892-1900
Journal: Journal of Inorganic Biochemistry - Volume 102, Issue 10, October 2008, Pages 1892-1900
نویسندگان
Begoña GarcÃa, Javier Garcia-Tojal, Rebeca Ruiz, Ruben Gil-GarcÃa, Saturnino Ibeas, Bruno Donnadieu, José M. Leal,