کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1316544 976466 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, crystal structure, magnetic property and oxidative DNA cleavage activity of an octanuclear copper(II) complex showing water–perchlorate helical network
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Synthesis, crystal structure, magnetic property and oxidative DNA cleavage activity of an octanuclear copper(II) complex showing water–perchlorate helical network
چکیده انگلیسی

A new octanuclear copper(II) complex has been synthesized and structurally characterized by X-ray crystallography: [Cu8(HL)4(OH)4(H2O)2(ClO4)2] · (ClO4)2 · 2H2O (1) (H3L = 2,6-bis(hydroxyethyliminoethyl)-4-methyl phenol). The complex is formed by the linkage of two terminal bimetallic cationic units and a tetranuclear μ3-hydroxo bridged dicubane core by a very short intramolecular hydrogen bond (O–H ⋯ O, 1.48(3) Å and the angle 175°). The coordination sphere of the terminal copper atoms is square pyramidal, the apical positions being occupied by water and a perchlorate ion. Complex 1 self-assembles to form a new type of water–perchlorate helical network [(H2O)2(ClO4)]∞ involving oxygen atoms of coordinated perchlorate ion and the two lattice water molecules through hydrogen-bonding interaction. The variable temperature-dependent susceptibility measurement (2–300 K) of 1 reveals a strong antiferromagnetic coupling, J1 = −220 cm−1 and J2 = −98 cm−1 (J1 and J2 representing the exchange constant within [Cu2+]4 and [Cu2+]2 units, respectively). The complex binds to double-stranded supercoiled plasmid DNA giving a Kapp value of 1.2 × 107 M−1 and displays efficient oxidative cleavage of supercoiled DNA in the presence of H2O2 following a hydroxyl radical pathway.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 101, Issue 1, January 2007, Pages 95–103
نویسندگان
, , , , , ,