کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1316592 | 1499480 | 2008 | 20 صفحه PDF | دانلود رایگان |
Synthetic modeling of tyrosinase (o-phenol ring hydroxylation) has emerged as a novel class of successful biomimetic studies. It is a well-established fact that the reaction of dioxygen with copper(I) complexes of m-xylyl-based ligands generate putative copper–oxygen intermediate species such as side-on peroxo {CuII2(μ-O2)}2+ [in some cases bis-oxo {Cu2III(μ-O)2}2+ in equilibrium with isomeric side-on peroxo], due to oxygen activation. Electrophilic attack of such species brings about monooxygenase activity by incorporating one of the oxygens to m-xylyl ring of the ligand and the other oxygen is reduced to hydroxide ion. The goal of this review is to provide a concise overview of the present day knowledge in this field of research to emphasize the important role the designed ligands play in eliciting the desired tyrosinase-like chemistry.
Journal: Journal of Inorganic Biochemistry - Volume 102, Issues 5–6, May 2008, Pages 1170–1189