کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1316632 | 976471 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Studies on the interaction of extended terpyridyl and triazine metal complexes with DNA
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Studies on the interaction of extended terpyridyl and triazine metal complexes with DNA Studies on the interaction of extended terpyridyl and triazine metal complexes with DNA](/preview/png/1316632.png)
چکیده انگلیسی
The interaction with duplex DNA of a series of 12 previously synthesised ruthenium (II) complexes incorporating extended terpyridines or analogous ligands is reported. The interaction was investigated using absorption spectroscopy and also, when possible, luminescence spectroscopy. Binding parameters for the interactions were estimated using established models. It was found that binding affinities are relatively large and their magnitude is somewhat dependent on the metal centre attached to the ligand. Viscosity studies reveal that all the complexes interact with DNA through groove binding and not intercalation. The variation in binding affinities of these complexes is rationalised by a consideration of electrostatic and steric factors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 100, Issue 8, August 2006, Pages 1314–1319
Journal: Journal of Inorganic Biochemistry - Volume 100, Issue 8, August 2006, Pages 1314–1319
نویسندگان
Clive Metcalfe, Chatna Rajput, Jim A. Thomas,