کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1316797 976482 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Crystal structure of ferric-yersiniabactin, a virulence factor of Yersinia pestis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Crystal structure of ferric-yersiniabactin, a virulence factor of Yersinia pestis
چکیده انگلیسی

Yersiniabactin (Ybt), the siderophore produced by Yersinia pestis, has been crystallized successfully in the ferric complex form and the crystal structure has been determined. The crystals are orthorhombic with a space group of P212121 and four distinct molecules per unit cell with cell dimensions of a = 11.3271(±0.0003) Å, b = 22.3556(±0.0006) Å, and c = 39.8991(±0.0011) Å. The crystal structure of ferric Ybt shows that the ferric ion is coordinated as a 1:1 complex by three nitrogen electron pairs and three negatively charged oxygen atoms with a distorted octahedral coordination. The molecule displays a Δ absolute configuration with chiral centers at N2, C9, C10, C12, C13, and C19 in R, R, R, R, S, S configurations, respectively. Few of the crystal structures of siderophores have been solved, and those which have been are of simple hydroxamate and catechol types such as ferrioxamine B and agrobactin. To our knowledge this is the first report of the ferric crystal structure of 5-member heterocycle siderophore.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 100, Issue 9, September 2006, Pages 1495–1500
نویسندگان
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