Synthesis, crystal structure, DNA and protein binding studies of novel binuclear Pd(II) complex of 6-methoxy-2-oxo-1,2-dihydroquinoline-3-carbaldehyde-4(N,N)-dimethylthiosemicarbazone

• Syntheses of new binuclear Pd(II) complex with thiosemicarbazone.
• The new Pd(II) complex interacts with calf thymus DNA via intercalation.
• The complex binds with bovine serum albumin more strongly than the free ligand.

A novel binuclear palladium(II) complex [(AsPh3)2ClPd(L)PdCl] (LPd2) has been synthesized by reacting 2-oxo-1,2-dihydroquinoline-3-carbaldehyde-4(N,N)-dimethylthiosemicarbazone (HL) with [PdCl2(AsPh3)2], and the molecular structure was confirmed by single crystal X-ray diffraction studies. The DNA interactions of the free ligand and of the complex have been evaluated by absorption and ethidium bromide (EB) competitive studies which revealed that the complex could interact with calf thymus DNA (CT-DNA) through intercalation. In addition, the interactions with bovine serum albumin (BSA) were also studied showing that the new binuclear palladium complex had a strong binding affinity with BSA.

A new binuclear 2-oxo-1,2-dihydroquinoline-3-carbaldehyde-4(N,N)-dimethylthiosemicabazone palladium(II) complex has been synthesized and characterized by the X-ray structure. Its binding properties towards calf thymus DNA and bovine serum albumin (BSA) have been evaluated.Figure optionsDownload as PowerPoint slide