Water soluble heterometallic potassium-dioxidovanadium(V) complexes as potential antiproliferative agents

• Two water soluble heterometallic potassium–dioxidovanadium polymers are reported.
• Both are characterized by single crystal X-ray diffraction analysis.
• Their antiproliferative activities towards adenocarcinoma cell lines are examined.
• One of them exhibits a high cytotoxic activity against colorectal carcinoma cells.

Two water soluble heterometallic potassium–dioxidovanadium polymers, [KVO2(L1)]n (1) and [KVO2(L2)(H2O)]n (2) [H2L1 = (2,3-dihydroxybenzylidene)-2-hydroxybenzohydrazide and H2L2 = (2,3-dihydroxybenzylidene)benzohydrazide], have been synthesized and characterized by IR, NMR, elemental analysis and single crystal X-ray diffraction. The antiproliferative potentials of 1 and 2 were examined towards human colorectal carcinoma (HCT116), and lung (A549) and breast (MCF7) adenocarcinoma cell lines. 1 exhibits a high cytotoxic activity against colorectal carcinoma cells (HCT116), with IC50 lower than those for cisplatin.

Graphical AbstractThe antiproliferative potentials of two water soluble heterometallic potassium–dioxidovanadium polymers [KVO2(L1)]n (1) and [KVO2(L2)(H2O)]n (2) were examined towards human colorectal carcinoma (HCT116), and lung (A549) and breast (MCF7) adenocarcinoma cell lines. 1 exhibits a high cytotoxic activity against colorectal carcinoma cells (HCT116).Figure optionsDownload as PowerPoint slide