کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1317197 | 976514 | 2007 | 6 صفحه PDF | دانلود رایگان |
The cell viability of human cancer cell lines treated with [5,10-bis(N-methyl-4-pyridyl)-15,20-diphenyl]porphinatoiron(III) (cis-FeMPy2P2P) has been estimated. The cis-FeMPy2P2P is a superoxide dismutase (SOD) mimic in vitro that exhibited a significant toxicity in cancer cell lines. This toxicity is rather due to pro-oxidant properties of the iron-porphyrin in vivo. We have demonstrated that there was the relationship between the LD50 values calculated from the viability of cancer cell lines treated with cis-FeMPy2P2P and the SOD activities of the cell lines. Furthermore, the inhibition of SOD by antisense S-oligonucleotide increased the cytotoxic effect of cis-FeMPy2P2P against cancer cells. These results suggest that SOD is a target enzyme for the cell death induced by cis-FeMPy2P2P as a new class of anticancer agents.
Journal: Journal of Inorganic Biochemistry - Volume 101, Issue 2, February 2007, Pages 261–266