کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1317441 976535 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Iron loading into ferritin can be stimulated or inhibited by the presence of cations and anions: A specific role for phosphate
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Iron loading into ferritin can be stimulated or inhibited by the presence of cations and anions: A specific role for phosphate
چکیده انگلیسی

Phosphate and other oxo-anions have been shown to stimulate the rate of iron loading into ferritin (J. Polanams, A.D. Ray, R.K. Watt, Inorg. Chem. 44 (2005) 3203–3209). This study was undertaken to determine if accelerated iron loading was a specific effect for phosphate and closely associated oxo-anions or if it was a general anion effect. Controls were also performed with mono-valent cations to determine the effect of these cations on iron loading into ferritin. Cations were shown to slow the rate of iron loading into ferritin. Fluoride and iodide were shown to slow the iron loading process of ferritin. Sulfate was also shown to slow iron loading into ferritin to a more significant extent than the cations or halides tested. The trigonal planar oxo-anions, carbonate and nitrate, did not inhibit or stimulate iron loading. We conclude that the increased rate of iron loading into ferritin is specific to phosphate and other closely associated tetrahedral oxo-anion analogs, that the effect is driven by the insolubility of the iron and anion complex, and that in general, cations and anions slow the rate of iron loading into ferritin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 99, Issue 12, December 2005, Pages 2270–2275
نویسندگان
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