کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1317468 976536 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Study on synthesis, structure, and DNA-binding of Ni, Zn complexes with 2-phenylquinoline-4-carboylhydrazide
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Study on synthesis, structure, and DNA-binding of Ni, Zn complexes with 2-phenylquinoline-4-carboylhydrazide
چکیده انگلیسی

2-Phenylquinoline-4-carboylhydrazide (HL), and its novel nickel(II), zinc(II) complexes [M(HL)2(L)]·2H2O·NO3 (M = Ni (1), M = Zn (2)), have been synthesized and characterized by elemental analysis, molar conductivity, and IR spectra. The crystal structure of [Ni(HL)2(L)]·2H2O·NO3 obtained from ethanol solution was determined by X-ray diffraction analysis, crystallized in the rhombohedral system, space group R3¯, Z = 18, a = 31.913(3) Å, b = 31.913(3) Å, c = 27.709(2) Å, α = 90°, β = 90°, γ = 120°, R1 = 0.0647. The interactions of the complexes and the ligand with calf thymus DNA had been investigated using UV–Vis spectra, fluorescent spectra, CD (circular dichroism) spectra, CV (cyclic voltammetry) and viscosity measurements. These compounds were tested against MFC (mouse forestomach carcinoma) cell lines. The complex 1 showed significant cytotoxic activity against MFC cell lines. The cleavage reaction on plasmid DNA has been monitored by agarose gel electrophoresis. Results suggest that the two complexes bound to DNA via a groove binding mode and the complexes can cleave pBR322 DNA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 103, Issue 2, February 2009, Pages 210–218
نویسندگان
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