کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1317721 1499470 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Water soluble fluorescent-magnetic perylenediimide-containing maghemite-nanoparticles for bimodal MRI/OI imaging
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Water soluble fluorescent-magnetic perylenediimide-containing maghemite-nanoparticles for bimodal MRI/OI imaging
چکیده انگلیسی

The protein shell of apoferritin-encapsulated maghemite nanoparticles was functionalized with two different red-emitting perylenediimide fluorophores (PDI). One glycosacharide-PDI complex has been synthesized for the first time to be labeled to apoferritin-encapsulated maghemite nanoparticles. Bifunctionality of maghemite@perylenediimide was demonstrated by both magnetic-core and fluorescent-labeled shell properties. SQUID measurements confirmed superparamagnetic behavior above 35 K. Fluorescence of perylenediimides is retained once attached to the magnetic nanoparticle. Moreover, fluorescence microscopy showed that one of these fluorescent-magnetic nanoparticles was specifically internalized in bifidobacteria without affecting cell viability. These results revealed that the dual-modal imaging probes of maghemite@perylenediimide nanoparticles have the potential to be used as optical/MR dual imaging agents.

Apoferritin-encapsulated maghemite nanoparticles were functionalized with red-emitting perylenediimide fluorophores. One of these nanoparticles was internalized in bifidobacteria without affecting cell viability. These results revealed that the water soluble bifunctional maghemite@perylenediimide nanoparticles have the potential to be used as optical/MR dual imaging agents.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 117, December 2012, Pages 205–211
نویسندگان
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