Interactions of quinoline antimalarials with hematin in solution

Quinoline antimalarial drugs such as chloroquine and related compounds are believed to act by targeting ferriprotoporphyrin IX (Fe(III)PPIX) in the form of hematin (H2O/HO–Fe(III)PPIX), its μ-oxo dimer ([Fe(III)PPIX]2O) or crystalline β-hematin ([Fe(III)PPIX]2) in the malaria parasite. Fe(III)PPIX is formed when the parasite digests host hemoglobin during its intraerythrocytic blood stage. This has led to a number of studies on the interaction of Fe(III)PPIX with quinoline antimalarials and related compounds. This article reviews the spectroscopy, thermodynamics and structures of Fe(III)PPIX–quinoline complexes in solution.