کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1321338 | 1499891 | 2014 | 4 صفحه PDF | دانلود رایگان |
• Base-mediated demetallation of N-1 and N-3 substituted Fischer tungsten–carbene uracil complexes were studied.
• Reaction on N-1 substituted Fischer tungsten–carbene uracil complexes gave excellent yield only using a large excess of base.
• A practical and efficient synthesis of pyrimidin-2-ones derivatives is described.
A practical and efficient synthesis of pyrimidin-2-one derivatives from Fischer carbene complex uracil-analogues through base-mediated elimination reactions is described. The scope of the protocol has been explored with the preparation of a variety of pyrimidin-2-one derivatives by base mediated demetallation of N-1 and N-3 substituted uracil Fischer carbenes.
Fischer carbene complex uracil analogues were used for the synthesis of pyrimidin-2-ones. A practical and efficient methodology was optimized and applied to the preparation of a variety of pyrimidin-2-one derivatives.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 749, 1 January 2014, Pages 47–50