Synthesis, characterization and antitumor activity of novel ferrocene derivatives containing pyrazolyl-moiety

• A series of novel ferrocene derivatives containing pyrazol-moiety were synthesized.
• Isomeric compounds 4 and 5 were gave crystals suitable for X-ray structural analysis.
• Compound 4d, 4j and 4k exhibited comparable in vitro antitumor activities.

A series of novel ferrocene derivatives containing pyrazolyl-moiety (4a–k, 5a–k) were synthesized. Their structures were characterized by 1H NMR, mass spectroscopy and element analysis. The crystals of isomeric compounds 4 and 5 were suitable for X-ray structural analysis. All the compounds were evaluated for their inhibitory activities against A549, HepG2 and MDA-MB-45 cell lines using the MTT method. Among them, compounds 4d, 4j and 4k exhibited comparable antitumor activities in vitro against A549 and MDA-MB-45 to the positive control 5-fluorouracil (5-FU).

A series of novel ferrocene derivatives containing pyrazolyl-moiety were synthesized. Isomeric compounds 4 and 5 gave crystals suitable for X-ray structural analysis. All the compounds were evaluated the antitumor activity. Among them, compounds 4d, 4j and 4k exhibited comparable activity.Figure optionsDownload as PowerPoint slide