Nickel-catalyzed (E)-selective semihydrogenation of internal alkynes with hypophosphorous acid

• Direct semihydrogenation of alkynes to (E)-alkenes.
• Easily handled and inexpensive reducing reagent hypophosphorous acid.
• High stereoselectivity.
• High functional-group-tolerance.

A facile Ni-catalyzed semihydrogenation of internal alkynes to (E)-alkenes using the cheap and easily handled hypophosphorous acid as a hydrogen donor was described. This reaction is featured by high reaction efficiency to produce the corresponding (E)-alkenes selectively.

A facile Ni-catalyzed semihydrogenation of internal alkynes to (E)-alkenes using the cheap easily handled hypophosphorous acid as hydrogen donor was described. This reaction is featured by high reaction efficiency affording the corresponding (E)-alkenes with a wide functional-group-tolerance.Figure optionsDownload as PowerPoint slide