A simple and efficient protocol for Suzuki coupling reactions of aryl chlorides and aryl bromides in aqueous DMF

• A simple, efficient, ligand-free Pd(OAc)2 catalyzed system for Suzuki reaction was developed.
• Pd(OAc)2, using Na2CO3 as base, can catalyze the Suzuki reaction of aryl halides in aqueous DMF.
• This protocol could be carried out without any presence of ligands and additives in air.
• This catalytic system was applicable to aryl bromide under mild reaction condition.
• With enhanced conditions, the protocol can be applied to activated aryl chlorides.

A simple, efficient and ligand-free palladium acetate catalyzed protocol was developed in aqueous N,N-dimethylformamide (DMF) under mild reaction conditions in the presence of Na2CO3 in air. This procedure showed good catalytic efficiency towards the Suzuki coupling of aryl bromide and arylboronic acid. Furthermore, under enhanced reaction conditions, various aryl chlorides could smoothly be coupled with arylboronic acids to afford biphenyls without any use of additives and ligands, and good yields were obtained in the Suzuki coupling of activated aryl chlorides.

A simple, efficient and ligand-free palladium acetate catalyzed protocol was developed in aqueous N, N-dimethylformamide (DMF) for the Suzuki coupling of aryl halides in the presence of Na2CO3 in air. Moderate to good yields were obtained for the Suzuki coupling of aryl bromide and activated aryl chloride.Figure optionsDownload as PowerPoint slide