An expedient ultrasonic assisted one-pot four component synthesis of novel ferrocene grafted pyrrolidine heterocycles via [3 + 2]-cycloaddition of azomethine ylides

• Synthesis of complex polycyclic heterocycles in accessible by other methods.
• Synthesis involves 1,3-dipolar cycloaddition reaction as the key step.
• It is a one pot multi component reaction with azomethine ylide as a dipole.

An expedient one-pot four component ultrasonic assisted synthesis of novel ferrocene grafted spiro-pyrrolidine heterocycles via [3 + 2]-cycloaddition of azomethine ylides is described. The protocol provides a mild reaction conditions, high yield of product in short reaction time, high regioselectivity, operational simplicity and applicable to a wide variety of ferrocene derived dipolarophiles for the efficient synthesis of ferrocene appended heterocycles. The structures of cycloadducts were confirmed by spectroscopic analysis. X-ray analysis of the products adds conclusive support to the proposed structure.

A facile one-pot four component ultrasonic assisted synthesis of novel ferrocene grafted spiro-indenoquinoxaline pyrrolidines via [3 + 2]-cycloaddition of azomethine ylides is described.Figure optionsDownload as PowerPoint slide